XINSHENG is an HPLC system manufacturer specializing in preparative liquid chromatography systems for compound isolation, purification and process scale-up. Our product portfolio covers laboratory-scale binary preparative HPLC systems and industrial chromatography equipment with isocratic, low-pressure gradient and high-pressure gradient elution configurations.
We manufacture and configure HPLC systems for pharmaceutical intermediates, active pharmaceutical ingredients (APIs), biopharmaceutical processing, natural product extraction, fine chemicals and food-related purification applications. System configurations can be developed around the separation method, processing capacity, chromatography column dimensions, detection requirements and process control needs.
Our HPLC systems are designed around different separation processes and production scales. Customers can choose between laboratory preparative instruments and larger industrial systems, with the elution configuration determined by the purification method.
| HPLC System Type | Available Configuration | Primary Selection Focus |
|---|---|---|
| Isocratic Preparative HPLC System | Constant mobile-phase composition during separation | Purification methods that operate with a fixed solvent composition |
| Low-Pressure Gradient Preparative HPLC System | LP600, LP1000, LP1500, LP2000, LP3000 and LP5000 | Industrial gradient purification, solvent proportioning and large-scale processing |
| High-Pressure Gradient Preparative HPLC System | Industrial high-pressure solvent delivery and gradient control configurations | Preparative processes requiring high-pressure gradient mixing and coordinated solvent delivery |
| 100 mL/min Binary Preparative HPLC System | M-Prep EC2010 touchscreen model with two EMP0100 pumps | Laboratory and semi-preparative purification with binary high-pressure gradient elution |
The selection of a preparative HPLC system depends on the chromatography method, solvent composition, column specifications and desired processing capacity. For applications requiring a different configuration, XINSHENG can review the equipment requirements and available customization options.
Laboratory and industrial preparative chromatography systems differ in more than physical size. The required solvent delivery capacity, sample injection method, column diameter, detection configuration, fraction handling and process control arrangement change as purification moves toward larger production quantities.
| Comparison | Laboratory Preparative HPLC | Industrial Preparative HPLC |
|---|---|---|
| Main Purpose | Compound isolation, method development and small-batch purification | Process scale-up, pilot production and larger-batch purification |
| Representative XINSHENG System | M-Prep EC2010 binary preparative HPLC system | LP series and industrial high-pressure gradient systems |
| Solvent Delivery | Preparative pumps selected for laboratory operating conditions | Higher-capacity solvent delivery, industrial piping and valve arrangements |
| Sample Introduction | Manual injection valve and sample loop in the EC2010 configuration | Process-specific sample introduction and optional sample pumping arrangements |
| Chromatography Columns | Prepacked columns and compatible smaller preparative columns | Larger chromatography columns selected according to process capacity |
| Fraction Collection | Optional fraction collection in the EC2010 configuration | Industrial collection valves and fraction handling configurations |
| Control Requirements | Instrument operation, method settings, detection and chromatogram monitoring | Coordinated control of pumps, valves, detectors, pressure monitoring and process functions |
For method transfer from laboratory to industrial scale, XINSHENG can review the existing chromatography conditions and equipment requirements to determine a suitable preparative system configuration.
The elution method is one of the main decisions when selecting a preparative HPLC system. XINSHENG offers different system configurations to accommodate constant solvent composition and programmed gradient separation.
Isocratic elution maintains a constant mobile-phase composition throughout the chromatography run. It is an appropriate configuration when the established separation method does not require solvent composition changes. System selection can focus on the required solvent delivery flow, sample introduction, column capacity and fraction collection method.
Low-pressure gradient systems proportion solvent streams before high-pressure delivery. This arrangement is relevant to industrial purification processes that require programmed mobile-phase composition changes.
XINSHENG's industrial LP series includes LP600, LP1000, LP1500, LP2000, LP3000 and LP5000 models. Configurations cover infusion pump flow ranges up to 5000 L/h, with a stated operating pressure range of 0–10 MPa and gradient composition range of 5%–95%.
Available system specifications also describe optional sample pumps, UV detection, mass flow measurement, pressure monitoring, pneumatic control valves and chromatography column configurations. The final configuration depends on the selected model and purification process.
High-pressure gradient chromatography uses separately controlled solvent delivery streams that are combined on the high-pressure side of the system. This arrangement allows solvent composition changes to be coordinated through the delivery system.
XINSHENG provides industrial high-pressure gradient configurations with coordinated pumps, detection instruments, control valves and column-related process functions. These systems are relevant to purification operations requiring controlled gradient elution and larger chromatography equipment.
The choice between low-pressure and high-pressure gradient systems should be based on the separation method, gradient requirements, flow and pressure conditions, process scale and actual equipment specifications.
A complete preparative HPLC system requires coordinated solvent delivery, injection, chromatographic separation, detection and fraction collection. However, the exact scope of supply differs between individual instrument models and industrial process configurations.
| Equipment | M-Prep EC2010 Configuration | Supply Status |
|---|---|---|
| Preparative HPLC Pumps | Two EMP0100 pumps, 100 mL/min each | Standard |
| UV Detector | EUD2000 UV detector, published wavelength range 190–400 nm | Standard |
| Sample Injection | Manual injection valve and 10 mL sample loop | Standard |
| Sample Loop Option | 20 mL loop | Optional |
| Dynamic Mixer | 316L preparative dynamic mixer | Standard |
| Online Filter | 316L online filter | Standard |
| Chromatography Workstation | LabChrom | Standard |
| Fraction Collector | Eight-channel collection option | Optional |
| Chromatography Column | ID30/40/50 prepacked column, ID50 spring column or compatible DAC50 series column | Optional |
This configuration is specific to the M-Prep EC2010. Industrial systems use different pump capacities, piping, valves, instrumentation and column arrangements. Customers should request the equipment configuration sheet and scope of supply for their selected HPLC system.
XINSHENG preparative HPLC systems are intended for chromatographic purification processes in pharmaceutical, biotechnology, natural product and fine chemical production. The selection of equipment depends on the properties of the target compounds, stationary phase, separation method and required processing quantity.
Pharmaceutical Intermediates and APIs: Preparative separation and purification of compounds during process development and manufacturing.
Biopharmaceutical Processing: Chromatography equipment for applicable biomolecule and pharmaceutical purification processes.
Natural Products and Plant Extracts: Separation of target compounds from complex botanical mixtures using suitable stationary phases and elution methods.
Fine Chemicals: Purification of chemical intermediates, synthesized compounds and specialty chemicals.
Food and Health Products: Chromatographic purification processes involving suitable food-related compounds and ingredients.
Specific separation performance, achievable purity and product recovery depend on the chromatography method and must be evaluated using process data. System specifications alone do not establish the outcome of a particular purification application.
When a purification method is transferred from laboratory experiments to preparative production, the new HPLC system must accommodate the intended processing quantity while maintaining appropriate chromatography conditions.
XINSHENG's product range includes preparative pumps, complete HPLC systems and larger chromatography columns for different process scales. System configuration can be reviewed using the established laboratory method and target production requirements.
Existing Separation Method: Mobile phase, stationary phase, gradient program, chromatograms and relevant operating conditions.
Column Specifications: Column inner diameter, bed height, packing material and particle size.
Sample Loading: Injection volume, sample concentration, loading quantity and required processing capacity.
Flow and Pressure: Existing linear velocity, system backpressure and maximum permissible pressure.
Purification Objectives: Target compound, required purity, recovery expectations and fraction collection requirements.
Production Environment: Available space, solvent handling, utilities and equipment operation requirements.
Where a larger chromatography column is required, the system can be evaluated alongside XINSHENG's preparative HPLC columns and dynamic axial compression columns. Column selection and system sizing should be coordinated with the purification method rather than determined by equipment capacity alone.
As a preparative HPLC system manufacturer, XINSHENG supports equipment customization for laboratory and industrial purification projects. Customers can discuss the required solvent delivery capacity, injection arrangement, chromatography column, detection method, process controls and equipment layout.
Solvent Delivery: Pump capacity, isocratic or gradient configuration and solvent channel requirements.
Sample Injection: Manual or process-specific injection arrangements, injection volume and sample handling requirements.
Detection: UV detection, available detector alternatives and wavelength requirements.
Chromatography Column: Column dimensions, stationary phase, operating pressure and packing configuration.
Fraction Collection: Collection channels, valve arrangements and fraction handling requirements.
Control and Monitoring: Operating interface, pressure monitoring, system signals and available control functions.
Equipment Layout: Installation dimensions, maintenance access, fluid connections and site requirements.
For industrial projects, technical discussions can also cover required documentation, installation arrangements, commissioning responsibilities and operating procedures. The final specifications and service scope should be established in the approved technical proposal.
XINSHENG's product range includes isocratic, low-pressure gradient, high-pressure gradient and binary preparative HPLC systems. The available equipment covers laboratory preparation and larger industrial purification configurations. Specific operating capacities depend on the selected system model.
Low-pressure gradient systems mix or proportion solvents before high-pressure delivery, while high-pressure gradient systems combine separately pressurized solvent streams. The choice depends on the chromatography method, solvent composition control, flow requirements and system design.
System configurations vary by model. For example, the M-Prep EC2010 lists fraction collection and several chromatography column options separately from its standard configuration. Buyers should confirm the included equipment and any required optional modules when requesting a quotation.
XINSHENG offers equipment customization for preparative chromatography projects. Requirements involving pump capacity, column selection, detection, solvent delivery, materials and control functions can be reviewed during system configuration. The available customization scope is determined by the selected product and technical requirements.
Useful information includes the existing separation method, mobile phase, column dimensions, stationary phase, injection quantity, flow rate, operating pressure, chromatographic results and target production capacity. These details help determine the appropriate system scale and required modules.
A detailed quotation should identify the system model, equipment configuration, operating specifications, materials, automation and software scope, chromatography column requirements, documentation, installation support and commercial terms. Any application-specific requirements should be included in the technical inquiry.
Whether you require a laboratory preparative HPLC instrument, an industrial gradient chromatography system or a custom configuration for purification scale-up, XINSHENG can review your process and equipment requirements.
Send us your target compound, current chromatography method, expected processing capacity, required purity, flow and pressure conditions, column requirements and preferred system configuration. Our team can discuss the available HPLC system models, configuration options and scope of supply before preparing a quotation.
For individual equipment rather than a complete system, refer to our HPLC system components and HPLC pump.
N Isometricelution Application
LP Gradient elution -low pressure Application
HP Gradient elution(high pressure)
100ml Binary Preparative HPLC System-Touchscreen Model
Provide Refurbishment Service
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